Phytoplenus Bioativos S.A. developed a technology that effectively isolates various biomolecules from the secondary metabolism of the plant Calendula officinalis L., such as saponosidic triterpenoid monoesters faradiols, calenduladiols and arnidiols. These bioactive compounds of therapeutic interest are processed into a high quality extract used in clinical dermatological preparations through the Phytoplenus Technology. The extract produced by the Phytoplenus technology based on Calendula officinalis L. promotes efficient wound healing in all aspects because it meets all of the features mentioned above.
The various bioactive compounds present in the extract – mainly triterpenoid monoesters faradiols – are immune modulators that help biochemical and cellular events follow their courses, thus preventing an exacerbated release of pro-inflammatory mediators such as prostaglandins and other eicosanoids, which usually cause inflammation and hyperalgesic pain. Other bioactive compounds present in this Phytoplenus extract are glycoside flavonoids of quercetin and isorramnectin, which are important because they reduce capillary fragility, and therefore aid in the angiogenesis and the growth of the healing tissue.
Phytoplenus Hydroglycolic Extract of Calendula officinalis 4% (PSA-EPD) is a pharmaceutical ingredient, and not a medication. The medication made of Phytoplenus Extract can only be obtained through a doctor’s prescription at pharmacies certified by Phytoplenus, as stated above.
TECHNICAL INFORMATION FOR PHYTOPLENUS CALENDULA EXTRACT | |
|---|---|
| Class | COMPONENT OF PHYTO-THERAPEUTIC MEDICATION |
| Official Botanical Name | Calendula officinalis L. |
| Popular Name | Calendula, Marigold |
| Family | Asteraceae |
| Part of Plant Used | Flower |
| Commercial Name | Hydroglycolic Extract of Calendula officinalis 4% |
| Manufactured By | Phytoplenus Bioativos S.A. Rua Wanda dos Santos Mullmann, 1501 CEP 83323-123 — Pinhais — PR CNPJ/MF Nº 10.704.205/0001-01 Information: Phone/Fax: (41) 3667-1717 E-mail: [email protected] Site: www.phytoplenus.com Made in Brazil |
| Responsible Technician | Estevan Bruginski / CRF-PR Nº 23447 |
| Form | Liquid |
| Packaging | High-density polyethylene (HDPE) bottle with sealable cap in 250 ml, 500 ml, and 1000 ml sizes. |
| Composition | Calendula officinalis L. 4% Excipients: BHT (Butylated hydroxytoluene), ethanol, polyethylene glycol, purified water. |
| Indications | Extract for dermic compounded preparations used as anti-inflammatory agent for healing skin and mucosae lesions (BLUMENTHAL et al., 1998; ESCOP, 1997). |
| Instructions for Compounding Medications Based on Phytoplenus Hydroglycolic Extract of Calendula officinalis 4% da Phytoplenus | Phytoplenus Hydroglycolic Extract of Calendula officinalis 4% must be prepared at compounding pharmacies which had been accredited and certified by Phytoplenus in accordance with current health regulations. For greater efficacy of the preparations, it is recommended that compounded formulations made from the Phytoplenus Hydroglycolic Extract of Calendula officinalis 4% be diluted with purified water to a concentration of 2%. |
